{"id":1019,"date":"2019-09-30T13:14:26","date_gmt":"2019-09-30T20:14:26","guid":{"rendered":"http:\/\/www.armenshirvanian.com\/podcast\/?p=1019"},"modified":"2019-09-30T13:14:35","modified_gmt":"2019-09-30T20:14:35","slug":"231-david-a-sinclair-anti-aging-research-and-understanding-in-lifespan","status":"publish","type":"post","link":"https:\/\/www.armenshirvanian.com\/podcast\/231-david-a-sinclair-anti-aging-research-and-understanding-in-lifespan\/","title":{"rendered":"231: David A. Sinclair | Anti-Aging Research And Understanding In &#8220;Lifespan&#8221;"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/doyshlwH_400x400.jpg\" alt=\"\" class=\"wp-image-1020\" width=\"336\" height=\"336\" srcset=\"https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/doyshlwH_400x400.jpg 400w, https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/doyshlwH_400x400-150x150.jpg 150w, https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/doyshlwH_400x400-300x300.jpg 300w\" sizes=\"auto, (max-width: 336px) 100vw, 336px\" \/><\/figure><\/div>\n\n\n\n<p>When it comes to anti-aging research, Dr. David A. Sinclair of Harvard Medical School is on the forefront of research and innovation. He joins on episode 231 to discuss his new book <em>Lifespan: Why We Age &#8211; and Why We Don&#8217;t Have To<\/em>.<\/p>\n\n\n\n<p>Dr. Sinclair, Ph.D., A.O.\u00a0is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his\u00a0work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995.<\/p>\n\n\n\n<p>He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. He was also on TIME magazine\u2019s 2014 list of the\u00a0\u201c100 most\u00a0influential people in the world\u201d.<\/p>\n\n\n\n<p>Show notes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dr. Sinclair&#8217;s background, and what led him into the field of anti-aging research<\/li><li>what it is about adversity that leads to a chemical response in the body, across sirtuins and more<\/li><li>how aging is not yet thought of as a disease, and how that can change through communication efforts<\/li><li>why society and people can seem stuck in a slowed form of evolution as compared with where we are headed<\/li><li>why studying organisms fighting adversity, similar to how Dr. Cockell studied extremophiles, is the way to find most answers<\/li><li>how stress at a cellular level is different from psychological stress that releases cortisol in the bloodstream<\/li><li>what it means to have senescent cells accumulate in the body as one ages over time<\/li><li>how an optic nerve was regrown in a mouse, and what that means for our potential nerve-based regrowth<\/li><li>what kinds of demands Dr. Sinclair has on his time with regards to the research he does<\/li><li>how the Horvath Clock represents true age of a person beyond external appearance and other metrics<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"231: David A. Sinclair | Anti-Aging Research And Understanding In &quot;Lifespan&quot;\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/HJvqE4amRgw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This was an enjoyable episode, and book, that is right on the forefront of aging research and technology. Dr. Sinclair is very active in this space, and it shows. You can check out his <a href=\"https:\/\/genetics.med.harvard.edu\/sinclair\/people\/sinclair.php\">website<\/a>, the <a href=\"https:\/\/www.amazon.com\/Lifespan-Why-Age_and-Dont-Have\/dp\/1501191977\">book on Amazon<\/a>, or some of his <a href=\"https:\/\/genetics.med.harvard.edu\/sinclair\/research.php\">research<\/a>.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/lifespan-9781501191978_lg.jpg\" alt=\"\" class=\"wp-image-1021\" width=\"231\" height=\"349\" srcset=\"https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/lifespan-9781501191978_lg.jpg 265w, https:\/\/www.armenshirvanian.com\/podcast\/wp-content\/uploads\/2019\/09\/lifespan-9781501191978_lg-199x300.jpg 199w\" sizes=\"auto, (max-width: 231px) 100vw, 231px\" \/><\/figure><\/div>\n<div class=\"powerpress_player\" id=\"powerpress_player_2537\"><audio class=\"wp-audio-shortcode\" id=\"audio-1019-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"http:\/\/media.blubrry.com\/thearmenshow\/www.armenshirvanian.com\/podcast\/episodes\/tas231davidasinclair.mp3?_=1\" \/><a href=\"http:\/\/media.blubrry.com\/thearmenshow\/www.armenshirvanian.com\/podcast\/episodes\/tas231davidasinclair.mp3\">http:\/\/media.blubrry.com\/thearmenshow\/www.armenshirvanian.com\/podcast\/episodes\/tas231davidasinclair.mp3<\/a><\/audio><\/div><p class=\"powerpress_links powerpress_links_mp3\" style=\"margin-bottom: 1px !important;\">Podcast: <a href=\"http:\/\/media.blubrry.com\/thearmenshow\/www.armenshirvanian.com\/podcast\/episodes\/tas231davidasinclair.mp3\" class=\"powerpress_link_pinw\" target=\"_blank\" title=\"Play in new window\" onclick=\"return powerpress_pinw('https:\/\/www.armenshirvanian.com\/podcast\/?powerpress_pinw=1019-podcast');\" rel=\"nofollow\">Play in new window<\/a> | <a href=\"http:\/\/media.blubrry.com\/thearmenshow\/www.armenshirvanian.com\/podcast\/episodes\/tas231davidasinclair.mp3\" class=\"powerpress_link_d\" title=\"Download\" rel=\"nofollow\" download=\"tas231davidasinclair.mp3\">Download<\/a><\/p><p class=\"powerpress_links powerpress_subscribe_links\">Subscribe: <a href=\"https:\/\/www.armenshirvanian.com\/podcast\/feed\/podcast\/\" class=\"powerpress_link_subscribe powerpress_link_subscribe_rss\" target=\"_blank\" title=\"Subscribe via RSS\" rel=\"nofollow\">RSS<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>When it comes to anti-aging research, Dr. David A. Sinclair of Harvard Medical School is on the forefront of research and innovation. He joins on episode 231 to discuss his new book Lifespan: Why We Age &#8211; and Why We Don&#8217;t Have To. Dr. Sinclair, Ph.D., A.O.\u00a0is a Professor in the Department of Genetics and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[124],"tags":[116,5,115],"class_list":["post-1019","post","type-post","status-publish","format-standard","hentry","category-interviews","tag-aging","tag-podcast","tag-show"],"_links":{"self":[{"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/posts\/1019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/comments?post=1019"}],"version-history":[{"count":2,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/posts\/1019\/revisions"}],"predecessor-version":[{"id":1023,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/posts\/1019\/revisions\/1023"}],"wp:attachment":[{"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/media?parent=1019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/categories?post=1019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.armenshirvanian.com\/podcast\/wp-json\/wp\/v2\/tags?post=1019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}